We for that reason conclude that CtIP contributes to the recruitment of Dna2 to DNA hurt sites via its non-catalytic role, most very likely bodily conversation with Dna2, but not as a nuclease
The absence of discrete subnuclear Dna2 foci in a Dna2-deficient qualifications in equally human and rooster cells confirmed the specificity of the immunostaining (Fig 5A, 5B and S3C Fig). IR-induced…