Name :
HAND2 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to HAND2
Tested applications :
WB, IF
Species reactivity :
Human, Mouse, Rat
Alternative names :
HAND2 antibody; DHAND2 antibody; Hed antibody; Thing2 antibody; bHLHa26 antibody; dHand antibody; heart and neural crest derivatives expressed 2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-217 of human HAND2 (NP_068808.1).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000IF 1:50 – 1:100
Background :
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5′-CANNTG-3′ (By similarity).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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