Name :
TLK1 Protein
Description :
Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. TLK1 has a function important for proper chromosome segregation and maintenance of diploid cells at mitosis in mammalian cells that could be mediated by reduced phosphorylation of histone H3 and condensation of chromosomes, although other explanations to the phenotype are possible.
Species :
Human
Uniprotkb :
Baculovirus-Insect Cells
Tag :
His,GST
Synonyms :
KIAA0137, PKU-beta, tousled like kinase 1, PKU-β
Construction :
A DNA sequence encoding the human TLK1 isoform 1 (Q9UKI8-1) (Met 1-Tyr 766) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Protein Purity :
> 88 % as determined by SDS-PAGE
Molecular Weight :
Approxiamtely 114 kDa
Endotoxin :
Formulatione :
Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% glyPlease contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution :
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Stability & Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping :
Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background :
Tousled-like kinase 1 (or protein kinase ubiquitous, PKU-beta/TLK1) is a serine/threonine protein kinase that is implicated in chromatin remodeling, DNA replication and mitosis. TLK1 has a function important for proper chromosome segregation and maintenance of diploid cells at mitosis in mammalian cells that could be mediated by reduced phosphorylation of histone H3 and condensation of chromosomes, although other explanations to the phenotype are possible.
References and Literature :
1. Sillje H.H.W., et al., 2001, Curr. Biol. 11:1068-73. 2. Beausoleil S.A., et al., 2004, Proc. Natl. Acad. Sci. USA. 101:12130-5. 3. Oppermann F.S., et al., 2009, Mol. Cell. Proteomics 8:1751-64. 4. Mayya V., et al., 2009, Sci. Signal. 2: RA46-RA46.
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