**Background** Histone deacetylases (HDACs) are enzymes that remove acetyl groups from lysine residues on histones, leading to a more condensed chromatin structure and the repression of gene transcription. Dysregulation of…
**Background** Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by the reactivation of the human JC polyomavirus (JCV). The virus…
**Background** Major depressive disorder is a complex psychiatric condition characterized by persistent low mood, anhedonia, and cognitive impairment, often associated with imbalances in monoamine neurotransmitters. The regulation of noradrenaline and…
**Background** Hypertension and cardiovascular diseases remain significant global health challenges, often requiring the modulation of calcium influx in vascular smooth muscle cells to manage blood pressure. Simultaneously, the role of…
The performance of long-acting drug delivery systems is ultimately defined by their in vitro release behavior, which serves as a critical predictor of in vivo efficacy and patient compliance. This…
The rational design of functional bionanomaterials demands precise control over molecular integration within biological scaffolds. In this study, the honeycomb-structured crystals of the LEAFY protein from Ginkgo biloba were exploited…
The longevity of resin-based composite (RBC) restorations is largely dependent on the stability of the resin-dentin bond interface. Over time, hydrolytic degradation, enzymatic breakdown, and thermal cycling can compromise adhesion,…
The stability and morphology of nanostructures in block polyelectrolyte systems are governed by a delicate balance between electrostatic correlations, counterion release, and ion pair formation. In this study, we investigate…
To determine whether RAD51AP1 is functionally required for the radiosensitizing effect of BRD4 inhibition, we performed rescue experiments in cervical cancer cell lines. We knocked down RAD51AP1 in ME-180 and…
The efficiency of photoelectrochemical (PEC) water splitting is fundamentally limited by the recombination of photogenerated electron-hole pairs. This study introduces a molecular-level strategy to overcome this challenge by utilizing conjugated…