Clostridium perfringens, a Gram-positive pathogen, expresses a surface adhesin protein critical for host colonization and virulence. This protein, Cpe0147, features an N-terminal adhesin domain followed by 11 tandem Ig-like repeat…
**Background** Fungal infections pose a significant threat to human health, particularly in immunocompromised patients, due to the ability of certain fungi to cause systemic and invasive diseases. A critical component…
Abdominal bloating remains a common and distressing postoperative complication following hepatic resection, significantly affecting patient recovery and quality of life. Despite advances in surgical techniques and perioperative care, many patients…
Lysosomal acid lipase (LAL) deficiency is a metabolic disorder characterized by the accumulation of cholesteryl esters and triglycerides within lysosomes, leading to systemic inflammation and multiorgan dysfunction. A key feature…
**Background** Rabies is a lethal viral zoonotic disease caused by the rabies virus (RABV), which primarily attacks the central nervous system. Once clinical symptoms appear, the disease is almost invariably…
Danmu injection, a traditional Chinese medicine derived from *Nauclea officinalis*, has been widely used in China for treating cold, fever, and sore throat. Despite its clinical application, the chemical profile…
In the present study, we investigated the potential mechanisms underlying the rapid development of tolerance to the antihyperalgesic effects of mu-opioid receptor (MOR) agonists under a neuropathic pain-like condition. Repeated…
Quercetin, a naturally occurring polyphenolic flavonoid, has demonstrated significant anti-diabetic properties in vivo. Despite its known benefits, the precise mechanism by which quercetin influences insulin secretion in pancreatic beta cells…
**Background** Type 2 diabetes mellitus (T2DM) and dyslipidemia are metabolic disorders characterized by impaired glucose homeostasis and abnormal lipid levels, which significantly increase the risk of cardiovascular disease. A key…
Oxidative stress has emerged as a critical factor in the pathophysiology of various neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. This condition arises when there is an imbalance…