Product Name :
BAA473
Description:
BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells.
CAS:
Molecular Weight:
574.87
Formula:
C36H62O5
Chemical Name:
dodecyl (4R)-4-[(1R,3aS,3bS,5aR,7R,9aS,9bS,11S,11aR)-3a,3b,5a,9b-tetrahydrogenio-7,11-dihydroxy-9a,11a-dimethyl-10-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoate
Smiles :
C[C@H](CCC(=O)OCCCCCCCCCCCC)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)[C@@H](O)[C@@]21C
InChiKey:
XWNJYRRKUUVMRN-OFUWCFFZSA-N
InChi :
InChI=1S/C36H62O5/c1-5-6-7-8-9-10-11-12-13-14-23-41-31(38)20-15-25(2)29-18-19-30-28-17-16-26-24-27(37)21-22-35(26,3)32(28)33(39)34(40)36(29,30)4/h25-30,32,34,37,40H,5-24H2,1-4H3/t25-,26-,27-,28+,29-,30+,32-,34-,35+,36-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells.|Product information|Molecular Weight: 574.Pozelimab supplier 87|Formula: C36H62O5|Chemical Name: dodecyl (4R)-4-[(1R,3aS,3bS,5aR,7R,9aS,9bS,11S,11aR)-3a,3b,5a,9b-tetrahydrogenio-7,11-dihydroxy-9a,11a-dimethyl-10-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoate|Smiles: C[C@H](CCC(=O)OCCCCCCCCCCCC)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)[C@@H](O)[C@@]21C|InChiKey: XWNJYRRKUUVMRN-OFUWCFFZSA-N|InChi: InChI=1S/C36H62O5/c1-5-6-7-8-9-10-11-12-13-14-23-41-31(38)20-15-25(2)29-18-19-30-28-17-16-26-24-27(37)21-22-35(26,3)32(28)33(39)34(40)36(29,30)4/h25-30,32,34,37,40H,5-24H2,1-4H3/t25-,26-,27-,28+,29-,30+,32-,34-,35+,36-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Trimethobenzamide Technical Information |Shelf Life: ≥12 months if stored properly.PMID:32861230 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BAA473 (0-33 µM; 24 hours; THP-1-Cas9 cells) treatment induces cell death in LPS-primed THP-1-Cas9 cells.|References:|Alimov I, et al. Bile acid analogues are activators of pyrin inflammasome. J Biol Chem. 2019 Mar 8;294(10):3359-3366.Products are for research use only. Not for human use.|
