Product Name :
Dihydrexidine
Description:
Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity. Dihydrexidine can stimulate YAP phosphorylation.
CAS:
123039-93-0
Molecular Weight:
267.32
Formula:
C17H17NO2
Chemical Name:
(6aR,12bS)-5H,6H,6aH,7H,8H,12bH-benzo[a]phenanthridine-10,11-diol
Smiles :
OC1C=C2CC[C@H]3NCC4C=CC=CC=4[C@@H]3C2=CC=1O
InChiKey:
BGOQGUHWXBGXJW-RHSMWYFYSA-N
InChi :
InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Methylcobalamin Epigenetics
Shelf Life:
≥12 months if stored properly.Ripretinib Purity & Documentation
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35169913
Additional information:
Dihydrexidine (DAR-0100) is a high potent, selective and full efficacy D1-like dopamine receptor (D1/D5) agonist with an IC50 of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity. Dihydrexidine can stimulate YAP phosphorylation.|Product information|CAS Number: 123039-93-0|Molecular Weight: 267.32|Formula: C17H17NO2|Chemical Name: (6aR,12bS)-5H,6H,6aH,7H,8H,12bH-benzo[a]phenanthridine-10,11-diol|Smiles: OC1C=C2CC[C@H]3NCC4C=CC=CC=4[C@@H]3C2=CC=1O|InChiKey: BGOQGUHWXBGXJW-RHSMWYFYSA-N|InChi: InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Dihydrexidine (DAR-0100) strongly increased YAP phosphorylation in U2OS cells.|In Vivo:|Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h. Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo.|Products are for research use only. Not for human use.|
