Product Name :
L-Leucine
Description:
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
CAS:
61-90-5
Molecular Weight:
131.17
Formula:
C6H13NO2
Chemical Name:
(2S)-2-amino-4-methylpentanoic acid
Smiles :
CC(C)C[C@H](N)C(O)=O
InChiKey:
ROHFNLRQFUQHCH-YFKPBYRVSA-N
InChi :
InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.|Product information|CAS Number: 61-90-5|Molecular Weight: 131.17|Formula: C6H13NO2|Chemical Name: (2S)-2-amino-4-methylpentanoic acid|Smiles: CC(C)C[C@H](N)C(O)=O|InChiKey: ROHFNLRQFUQHCH-YFKPBYRVSA-N|InChi: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 8.33 mg/mL (63.51 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|L-Leucine (10 mM) treatment impairs endocrine progenitor cell development.Pancreatin Epigenetics In E13.Ganciclovir custom synthesis 5 rat pancreatic explants, in absence of added L-Leucine, Ngn3 mRNA levels increased after 1 day of culture, peaked on day 3, and then decreased.PMID:31613534 When L-Leucine is added, a dramatic decrease is observed in Ngn3 mRNA levels. This decrease in Ngn3 mRNA levels was paralleled by a decrease in the number of Ngn3-expressing cells (4728±408 vs. 959±28; PIn Vivo:|L-Leucine (24 g/kg diet) combined with Resveratrol (12.5 mg/kg diet) to diet-induced obese (DIO) mice increases adipose Sirt1 activity. Combination results in significant reductions in body weight, weight gain, visceral adipose tissue mass, fat oxidation and heat production in mice.|References:|Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.Products are for research use only. Not for human use.|
