Accessible repository that will not issue DOIs. The raw sequencing reads are available through the SRA (Sequence Read Archive) NCBI database below the accession quantity PRJNA750794. Acknowledgments: The authors are extremely grateful towards the reviewers for their constructive enable inside the improvement of this manuscript. Conflicts of Interest: The authors declare that they have no conflict of interest.
coatingsArticleDataset on a Small-Scale Film-Coating Process Developed for Self-Expanding 4D Printed Drug Delivery DevicesMarco Uboldi, Alice Melocchi , Saliha Moutaharrik , Matteo Cerea , Andrea Gazzaniga and Lucia ZemaSezione di Tecnologia e Legislazione Farmaceutiche “M. E. Sangalli”, Dipartimento di Scienze Farmaceutiche, Universitdegli Studi di Milano, 20133 Milan, Italy; [email protected] (M.U.); [email protected] (S.M.); [email protected] (M.C.); [email protected] (A.G.); [email protected] (L.Z.) Correspondence: [email protected]; Tel.: +39-02-Citation: Uboldi, M.; Melocchi, A.; Moutaharrik, S.; Cerea, M.; Gazzaniga, A.; Zema, L. Dataset on a Small-Scale Film-Coating Process Developed for Self-Expanding 4D Printed Drug Delivery Devices. Coatings 2021, 11, 1252. https://doi.org/10.3390/ coatings11101252 Received: 1 September 2021 Accepted: 9 October 2021 Published: 14 OctoberAbstract: Film-coating is broadly applied in pharmaceutics to improve aspect/taste and mechanical properties of dosage forms, to guard them from the environment and to modify their release functionality. In this respect, a film-coating YB-0158 References procedure was recently involved inside the development of 4D printed prolonged-release systems intended for organ retention. For the duration of coating processes, liquid formulations are sprayed onto moving cores, whose shape, weight and surface qualities are important to attain a homogeneous film. Devices of complex shapes, composed of sensible materials and fabricated by hot-processing tactics, such as extrusion and fused deposition modeling 3D printing, may possibly be poorly compatible together with the specifications of regular coating methods, e.g., need for spherical substrates with smooth surface and stable under method temperatures. This work was aimed at evaluating, at a tiny scale level, the feasibility of a versatile gear for film-coating of rod-shaped extruded and printed prototypes with distinct section. Gear design and style and set up of method parameters had been performed beginning from polymeric solutions and suspensions and deciding on as cores 50 mm-long rod-shaped samples depending on shape memory poly(vinyl alcohol). Integrity and thickness on the applied layer and its impact on shape memory and release overall performance of prototypes have been investigated. Keyword phrases: film-coating; controlled release; shape memory impact; hot melt extrusion; fused deposition modeling; 4D printing; poly(vinyl alcohol); methacrylic acid copolymers1. Introduction Accessibility of manufacturing methods based on hot-processing and availability of smart polymers (e.g., materials changing their shape/characteristics in response to an external stimulus) has opened new possibilities in pharmaceutics, by far the most interesting ones regarding 4D printing [1]. Simultaneously, the accomplishment of challenging therapeutic goals hitherto deemed unattainable and the development of personalized drug items through small-scale production processes could turn into a viable reality [7]. In prior works, self-expanding systems according to Namodenoson Formula pharmaceutical-grade po.
