nary embolism [PE] and acute coronary syndrome). The other four were doing prophylactic LMWH for no clinical reason. VTE moderate-risk cohort (n = 16), 11 had LMWH – 5 individuals on a therapeutical dose resulting from the main diagnosis and/or because of other comorbidities and also the remaining six on a prophylactic dose. Among these six patients, five had a low BR (7) and the researchers agreed using the prescription. The remaining patient had an Enhance BR score 7, which gave a major BR of four,1 (worldwide BR 7,9 ). For the reason that VTE threat was decrease (1,five ), we feel that this prophylactic LMWH was inappropriate. Within the subgroup with out LMWH (n = 5), all individuals had a low BR (big BR 0,four ; any hemorrhage threat 1,five ). VTE high-risk cohort (n = 8), six individuals had LMWH (5 – prophylactic dose; 1- therapeutical dose). Amongst the five patients with prophylactic dose, two sufferers had high BR. The patient with LMWH therapeutical dose had a PE along with a low BR. Within the VTE high-risk level, two pts have been not performing LMWH (1- higher BR; 1- low BR). Conclusions: 13,2 of individuals have been inadequately prescribed prophylactic LMWH. Amongst these with formal indication to prophylactic LMWH, 15,eight have been not doing it. Background: Unique research indicate a frequency of postoperative thrombosis from 20 to 59 . Additional than 70 of venous thrombosis after endoscopic interventions are asymptomatic and undiagnosed (Cushman M., 2007). However, in three.9 of situations they be accompanied E. Shorikov; P. Shorikov; D. Shorikova Bukovinian State Healthcare University, Chernivtsy, Ukraine PO186|Efficacy of Preoperative Prevention in Venous Thromboembolism at Endoscopic Urological Interventions Background: Anticoagulant therapy (ACT) with vitamin K antagonists (AVC) and direct oral anticoagulants (DOAC) requires an assessment of such risk aspects as concomitant pathology and its therapy. Aims: The aim will be to analyze the factors contributing towards the development of Leishmania Inhibitor Storage & Stability hemorrhagic complications on the background of ACT. Procedures: The evaluation from the case histories of 50 patients admitted for the Initial State Clinical Hospital named right after E. E. Volosevich within the period 2014020 was produced. The presence of causes, outcomes of complications, their frequency, concomitant pathology, the amount of INR (international normalized ratio) and blood pressure (BP) during hospitalization were studied. Results: 50 sufferers (23 girls and 22 guys) aged 46 to 83 years (Iu = 67) who received the ACT had been hospitalized using a diagnosis of “hemorrhagic stroke/intracranial hemorrhage”, confirmed clinically and on CT. Fatal IL-5 Antagonist Biological Activity outcome in 40 (n = 20) of sufferers. 37 patients (74 ) took Warfarin, 13 patients (26 ) – DOAC. 6 patients received Omeprazole (12 ), five – Digoxin (ten ), 1 Rosuvastatin (two ), 17 – Atorvastatin (34 ). Taking these drugs with each other with Warfarin requires monitoring the degree of hypocoagulation. At the admission of 16 individuals (32 ) with blood pressure within: 160 / 10079 / 109 and 20- (40 ) having a blood pressure of 180/110 or larger. Uncontrolled blood pressure can enhance the threat of hemorrhagic complications. 40 (n = 20) of patients had impaired renal function, liver 20 (n = 10), thyroid 12 (n = three). The INR value in admission was far more than 3 in 50 (n = 25) of individuals taking AVC-excessive hypocoagulation. Conclusions: BP, impaired kidney and liver function, their therapy can raise the rate of fatal bleeding. It is actually necessary to correct the concomitant pathology, to assess the pharmacokinetics in the drugs and the patient ‘s adherence to treatme
