nuscript. Funding The BIGPIC trial is supported by the National Heart, Lung, and Blood Institute from the National Chk2 Inhibitor custom synthesis Institutes of Health beneath award number 5R01HL125487. The content is solely the duty in the authors and doesn’t necessarily represent the official views with the National Institutes of Overall health. Samuel Ruchman was supported by the American Heart Association 2017 Student Scholarship in Cardiovascular Disease. Competing interests None declared. Patient consent for publication Not necessary. Ethics approval The BIGPIC trial is approved by the Institutional Review Boards in the Icahn School of Medicine at Mount Sinai and the NYU Grossman College of Medicine, both in New York, NY, and by the Institutional Analysis and Ethics Committee at Moi University, Eldoret, Kenya. Provenance and peer evaluation Not commissioned; externally peer reviewed. Data availability statement Information are obtainable upon affordable request. Data might be created accessible upon affordable request to the corresponding author and approval by the AMPATH Investigation System. Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and might not have been peer-reviewed. Any opinions or suggestions discussed are solely those in the author(s) and usually are not endorsed by BMJ. BMJ disclaims all liability and duty arising from any reliance placed around the content material. Exactly where the content consists of any translated material, BMJ does not warrant the accuracy and reliability on the translations (like but not restricted to regional regulations, clinical suggestions, terminology, drug names and drug dosages), and isn’t responsible for any error and/or omissions arising from translation and adaptation or otherwise. Open access This can be an open access post distributed in accordance using the Creative Commons Attribution Non Industrial (CC BY-NC four.0) license, which permits other folks to distribute, remix, adapt, create upon this work non-commercially, and license their derivative functions on distinct terms, provided the original perform is appropriately cited, appropriate credit is provided, any alterations made indicated, plus the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. ORCID iDs Samuel G Ruchman http://orcid.org/0000-0002-1950-0924 Allison K Delong http://orcid.org/0000-0001-8660-8073 Rajesh Vedanthan http://orcid.org/0000-0001-7138-9 Robalino JD, Macy M. Peer effects on adolescent smoking: are common teens extra influential PLoS 1 2018;13:e0189360. 10 Campbell R, Starkey F, Holliday J, et al. An informal school-based peer-led intervention for smoking prevention in adolescence (help): a cluster randomised trial. Lancet 2008;371:159502. 11 Moore S, DYRK4 Inhibitor supplier Salsberg J, Leroux J. Advancing social capital interventions from a network and population health perspective. In: Kawachi I, Takao S, Subramanian SV, eds. Worldwide perspectives on social capital and health. New York, NY: Springer, 2013: 18903. 12 Centola D. An experimental study of homophily inside the adoption of well being behavior. Science 2011;334:12692. 13 Modest ML. Weak ties and the core discussion network: why men and women consistently go over important matters with unimportant alters. Soc Networks 2013;35:4703. 14 Hurlbert JS, Haines VA, Beggs JJ. Core networks and tie activation: what sorts of routine networks allocate resources in nonroutine conditions Am Sociol Rev 2000;65:59818. 15 Perry BL, Pescosolido BA, Borgatti SP. Egocentric network analysis: founda
