Risk of UC. Folate, a water-soluble B vitamin in green leafy vegetables, citrus fruits, and legumes, is definitely the initial methyl donor in methionine biosynthesis [10]. Folate insufficiency disrupts the transfer from the one-carbon units involved in all biochemical S1PR2 Antagonist Source reactions such as plasma homocysteine determinants and SAM synthesis [11,20]. A earlier study investigated the 10-y PAK1 Inhibitor Purity & Documentation trends in plasma folate levels in Taiwanese people by means of 3 national NAHSIT surveys performed in 199321996, 199922000, and 200522008 and reported related plasma folate levels of about 8 ng/mL in males and 11 ng/mL in females; on the other hand, the prevalence of folate deficiency (,3 ng/mL) enhanced in the course of these 10-y periods, specifically for men [12]. In our study, the median worth of plasma folate levels was related to that reported by Chen et al. but was larger than that reported in other research [12,21,22].Association of DNMT Polymorphism and Folate with the Danger of UCTable 2. Associations in between the levels of plasma folate and UC danger by using multivariate logistic regression models.ORa (95 CI) 1.01 (0.99.03) ref. 2.57 (1.73.84) ref. 0.42 (0.27.65) 0.44 (0.28.68) ref. 0.41 (0.26.68) 0.42 (0.26.68) 0.46 (0.28.75) ORb (95 CI) 1.02 (0.99.04) ref. 2.06 (1.34.15) ref. 0.48 (0.30.76) 0.61 (0.38.97) ref.# 0.46 (0.27.77) 0.49 (0.29.83) 0.66 (0.39.11)Plasma folate (ng/mL) Median six S.D. .six #6 ,7.88 7.883.17 13.17 ,six.75 6.75.83 9.834.9 14.9 Incidence instances Median 6 S.D. .6 #6 ,7.88 7.883.17 13.17 ,six.75 6.75.83 9.834.9 14.9 Prevalence situations Median six S.D. .6 #6 ,7.88 7.883.17 13.17 ,6.75 six.75.83 9.834.9 14.aUC patients N = 192 7.7361.23 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31) N = 104 7.2861.33c 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31) N = 88 8.4562.17c 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31)Controls N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15) N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15) N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15)0.99 (0.97.02) ref. three.09 (1.90.01) ref. 0.34 (0.19.61) 0.37 (0.22.65) ref. 0.38 (0.21.71) 0.33 (0.18.62) 0.37 (0.20.68)1.01 (0.99.04) ref. two.43 (1.45.06) ref. 0.40 (0.22.73) 0.53 (0.30.95) ref. 0.44 (0.23.84) 0.39 (0.20.76) 0.53 (0.28.03)1.03 (0.99.05) ref. 2.11 (1.24.60) ref. 0.52 (0.29.92) 0.50 (0.27.90) ref.# 0.44 (0.22.00) 0.53 (0.28.00) 0.56 (0.29.08)1.03 (0.99.05) ref. 1.76 (1.01.08) ref. 0.56 (0.31.01) 0.67 (0.36.25) ref. 0.45 (0.23.91) 0.60 (0.31.18) 0.76 (0.38.51)OR values had been adjusted for age and gender. OR values were adjusted for age, gender, educational level, and cumulative cigarette smoking. p = 0.1772 by Student t-test. p,0.05 by trend test; #0.1,p,0.05 by trend test. doi:ten.1371/journal.pone.0104968.tb cMoreover, in our study, the prevalence of folate insufficiency was greater than that in other research, ranging from five to 15 [22]. The differences in the prevalence of folate insufficiency could be attributed to the ethnic variance of dietary habits or individual susceptibility to polymorphisms in metabolizing folate-related genes for instance DNMT3A and 3B. Previous studies have indicated a unfavorable association amongst plasma.
