Es, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia?2013 Phang et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of your Creative Commons Attribution License (creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, offered the original perform is correctly cited.Phang et al. BMC Complementary and Option Medicine 2013, 13:243 biomedcentral/1472-6882/13/Page 2 ofBackground Alpinia species, from the Zingiberaceae household have been extensively studied for their chemical and biological properties . Based around the ethnobotanical research, numerous species of this genus have already been p38 MAPK Agonist Formulation applied in traditional medicine, and within the preparations and flavorings of meals in many Asian nations. Among the Alpinia species, the rhizomes of Alpinia galanga have already been broadly employed as spice and inside the treatment of stomachic in China and Thailand; coughs, asthma, bronchitis, headache, inflammation, rheumatoid arthritis and colic in Malaysia [2,3]. One wild species, Alpinia mutica has been employed to treat stomach upset by natives and it has also been reported to show great antioxidant and cytotoxic anticancer properties . Some novel compounds isolated from the species of Alpinia had been identified to possess anti-cancer, antiinflammatory, anti-spasmodic, anti-ulcerogenic, neuroprotective, analgesic, hepatoprotective and cardioprotective properties . As a result of its wide therapeutic values, it truly is of terrific interest to conduct much more research on the unexplored species from this genus which may possibly possess medicinal properties, yet has not been completely studied. Within this endeavour, Alpinia pahangensis was hence selected for investigation. Alpinia pahangensis, a wild ginger, occcuring much less prevalent inside the genus, can be a perennial plant distributed in the lowlands of Pahang, Malaysia. The rhizomes of A. pahangensis happen to be employed by tribal natives for relieving flatulence. Nonetheless, there’s a restricted study on the biological activity from the A. pahangensis. A current report by Awang et al.  showed that the essential oil extracted from the rhizomes and leaves of Alpinia pahangensis had excellent antimicrobial activity against Staphylococcus aureus strains and selected fungi. Free of charge radicals created in our physique due to aerobic respiration and substrate oxidation, may cause oxidative pressure which might contribute to the improvement of a number of illnesses which includes cancer, Alzheimer’s illness, aging, diabetes, Parkinson disease and atherosclerosis [7-13]. Overproduction of free of charge radicals in our bodies may very well be rising on account of pollution along with other mTOR Inhibitor Source external things, and their removal by our antioxidant systems could be decrease than prior to as a consequence of numerous components related to our way of life among other individuals. Oxidative tension causes really serious damage to significant cellular macromolecules for instance protein and DNA. On the other hand, the production of no cost radicals may be balanced by antioxidant actions of endogenous enzymes too as organic and synthetic antioxidants [14,15]. Antioxidants exert its action by way of quite a few mechanisms such as prevention of chain initiation, chelating of transition metal ion catalysts, decomposition of peroxidases, prevention of continued hydrogen abstraction and radical scavenging .These deleterious effects of totally free radicals have drawn the attentions of scientists for the value of antioxidants in prevention and therapy of illnesses . Thus, there has been increasing interest.