The past half century. Among these, the therapeutic use of HSPs could be the most promising. HSPs play a crucial part in neuroprotection by keeping protein homeostasis and by regulating apoptosis. Neurons could be protected by up-regulating the expression of HSPs or reducing the degradation of HSPs applying a protein synthesis inhibitor which include cycloheximide. Inside the close to future, HSPs may be utilized clinically to prevent or treat HIE in the early stage to lower brain injury.Author contributions: HJ performed the evaluation with constructive discussion; WNJ revised the paper; XS conceived and designed the perform;Hua et al. / Neural Regeneration Study. 2017;12(1):153-160.CH and GZ wrote the paper. All authors approved the final version of this paper. Conflicts of interest: None declared. Plagiarism verify: This paper was screened twice working with CrossCheck to verify originality before publication. Peer evaluation: This paper was double-blinded and stringently reviewed by international specialist reviewers.
International Journal ofEnvironmental Analysis and Public HealthArticlePomegranate (Punica granatum) Juice Shows Antioxidant Activity against Cutaneous Leishmaniasis-Induced Oxidative Pressure in Female BALB/c MiceBadriah Alkathiri 1 , Manal F. El-Khadragy 1,2,3, ID , Dina M. Metwally 1,2,4, , Ebtesam M. Al-Olayan 1,two , Muhammed A. Bakhrebah five and Ahmed E. Abdel Moneim1 2 three 4IDDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, KSA; badara25.ba@gmail Chair Vaccines Study of Infectious Illnesses, Faculty of Science, King Saud University, Riyadh 11451, KSA; [email protected] Division of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt; boudy33sa@gmail Parasitology Division, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt Life Science Environment Study Institute/Director, National Center for Genome Technology, KACST, Riyadh 12371, Saudi Arabia; [email protected] Correspondence: manalelkhadragy@yahoo (M.F.E.-K.); mdbody7@yahoo (D.M.M.)Received: five November 2017; Accepted: six December 2017; Published: 18 DecemberAbstract: Leishmania species are parasites that multiply within phagocytes and trigger numerous clinical diseases characterized by single or multiple ulcerations. Among the list of complications that will induce tissue damage and the resulting scars is triggered by secondary bacterial infections. Research to find new, helpful, and protected oral drugs for treating leishmaniasis are being carried out since quite a few decades, owing to the difficulties related using the use of antimonials offered. Previously, the antiparasitic and antioxidant properties of Punica granatum (pomegranate, P.TGF beta 2/TGFB2 Protein web granatum) happen to be reported.TRAIL/TNFSF10 Protein Accession As a result, within the present study, we aimed to investigate the antileishmanial activity of pomegranate aqueous juice in vitro and in female BALB/c mice.PMID:24381199 A 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in Leishmania big promastigotes and alterations in the antioxidant status, liver function, and skin histological changes in L. major-infected mice orally treated with pomegranate juice alone and in combination together with the antibiotic ciprofloxacin, were employed to investigate the in vitro and in vivo antileishmanial activity of pomegranate juice, respectively. Oral P. granatum juice remedy significantly lowered the average size of cutaneous leishmaniasis lesions compared with that of the untreated mice. This antileishmanial activity of P. granatum was asso.
