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Name :
GM2A antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GM2A Mouse Monoclonal antibody. Positive WB detected in Hela cells, human placenta tissue. Observed molecular weight by Western-blot: 22 kDa

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
Ganglioside GM2 activator antibody; GM2 AP antibody; GM2 ganglioside activator antibody; GM2A antibody; SAP 3 antibody

Immunogen :
Human GM2A Recombinant protein (His tag)

Isotype :
Mouse IgG2a

Preparation :
This antibody was obtained by immunization of GM2A recombinant protein (Accession Number: NM_000405). Purification method: Protein A purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000

Background :
GM2A, also named as GM2-AP and SAP-3, is the large binding pocket which can accommodate several single chain phospholipids and fatty acids. GM2A also exhibits some calcium-independent phospholipase activity. It plays a key role in the degradation of ganglioside GM2 (GM2). GM2A stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel