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Name :
GMF-beta antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GMF-beta Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue. Positive WB detected in rat brain tissue, human brain tissue, human heart tissue, mouse brain tissue, mouse heart tissue. Observed molecular weight by Western-blot: 17 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
Glia maturation factor beta antibody; glia maturation factor antibody; beta antibody; GMF antibody; GMF beta antibody; GMFB antibody; GMF-β antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GMF-beta recombinant protein (Accession Number: BC005359). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
GMFB, Glia maturation factor beta, is a nerve growth factor implicated in nervous system development. It was reported that GMF-beta promotes the phenotypic expression of glia and neurons and inhibits the proliferation of their respective tumors in culture cells. GMF-beta protein is specific to the brain where it is expressed in glial cells (mainly astrocytes) and insome neurons. Higher levels of GMFB were found in the central nervous system, except for the spinal cord, and in thymus and colon.

References :
Li YL, Ye F, Cheng XD. Identification of glia maturation factor beta as an independent prognostic predictor for serous ovarian cancer. European journal of cancer (Oxford, England : 1990). 46(11):2104-18. 2010. Nam J, Onitsuka I, Hatch J. Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development (Cambridge, England). 140(7):1475-85. 2013. Kempuraj D, Thangavel R, Yang E. Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators. PloS one. 10(8):e0135776. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel