Name :
GMFG antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GMFG Rabbit Polyclonal antibody. Positive IHC detected in human lung cancer tissue, human heart tissue, human kidney tissue, human placenta tissue, human spleen tissue, human testis tissue. Positive WB detected in rat brain tissue, human heart tissue, human placenta tissue, mouse placenta tissue. Positive IP detected in mouse spleen tissue. Observed molecular weight by Western-blot: 17 kDa
Tested applications :
ELISA, IHC, IP, WB
Species reactivity :
Human, Mouse, Rat; other species not tested.
Alternative names :
Glia maturation factor gamma antibody; glia maturation factor antibody; gamma antibody; GMF GAMMA antibody; GMFG antibody
Immunogen :
Human GMFG Recombinant protein (GST tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GMFG recombinant protein (Accession Number: NM_004877). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
GMFG (glia maturation factor-γ), is a 17 kDa protein that belongs to the GMF subfamily of the larger Actin-binding protein ADF family. In adult rat, the GMFG mRNA is predominantly expressed in the thymus, testis, and lung. GMFG is considered a hematopoietic-specific protein that may mediate the pluripotentiality and lineage commitment of human hematopoietic stem cells. GMFG has several serine/threonine (Ser/Thr) phosphorylation sites, and can be phosphorylated at N-terminal serine, and its phosphorylation is enhanced by coexpression of dominant active Rac1 and Cdc42. Expression of GMFG enhances actin-based cellular functions such as migration and tube-formation in endothelial cells. GMFG expression is also significantly increased in a cardiac ischemia/reperfusion model where inflammation and angiogenesis take place actively.
References :
Lippert DN, Wilkins JA. Glia maturation factor gamma regulates the migration and adherence of human T lymphocytes. BMC immunology. 13:21. 2012. Nam J, Onitsuka I, Hatch J. Coronary veins determine the pattern of sympathetic innervation in the developing heart. Development (Cambridge, England). 140(7):1475-85. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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