Name :
GNB1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GNB1 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, HeLa cells, mouse brain tissue. Positive IHC detected in human pancreas cancer tissue, human gliomas tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 37 kDa
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
GNB1 antibody; Transducin beta chain 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GNB1 recombinant protein (Accession Number: XM_047418071). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IHC: 1:20-1:200IF: 1:20-1:200
Background :
GNB1(Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1) belongs to the WD repeat G protein beta family.The guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems and the beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.GNB1 can form dimers with all gamma subunits analyzed(PMID:12782285).
References :
Haider NB, Mollema N, Gaule M. Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransduction. Experimental eye research. 89(3):365-72. 2009. Okae H, Iwakura Y. Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice. Developmental dynamics : an official publication of the American Association of Anatomists. 239(4):1089-101. 2010. Saba LM, Bennett B, Hoffman PL. A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission. Neuropharmacology. 60(7-8):1269-80. 2011.
Related websites: https://www.medchemexpress.com/antibodies.html
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