Name :
GOLGA2/GM130 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GOLGA2/GM130 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, human spleen tissue. Positive IHC detected in human testis tissue, human kidney tissue, human placenta tissue. Positive IF detected in HEK-293 cells. Positive FC detected in HEK-293 cells. Observed molecular weight by Western-blot: 130 kDa
Tested applications :
ELISA, WB, IHC, IF, FC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
GM130 antibody; GM130 autoantigen antibody; GOLGA2 antibody; Golgin 95 antibody; Golgin subfamily A member 2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GOLGA2/GM130 recombinant protein (Accession Number: BC014188). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IHC: 1:20-1:200IF: 1:10-1:100
Background :
GOLGA2, also known as GM130, is a 130 kDa cis-Golgi matrix protein which is one component of the detergent and salt resistant Golgi matrix. It is a peripheral membrane protein highly bound to Golgi membrane and localized mainly at the cytoplasmic face of cis-Golgi membrane. Together with its interacting partner proteins, including p115, giantin, GRASP65, and Rab GTPase, GOLGA2/GM130 is involved in the regulation of ER-to-Golgi transport and also in the maintenance of the Golgi structure. Emerging evidence suggest that the GOLGA2/GM130 has potential roles in the control of glycosylation, cell cycle progression, and higher order cell functions such as cell polarization and directed cell migration. (PMID: 20197635)
References :
Fuller SJ, McGuffin LJ, Marshall AK. A novel non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3). The Biochemical journal. 442(3):595-610. 2012. Yang M, Kozminski DJ, Wold LA. Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer. Breast cancer research and treatment. 134(2):603-15. 2012. Liang B, Peng P, Chen S. Characterization and proteomic analysis of ovarian cancer-derived exosomes. Journal of proteomics. 80:171-82. 2013. Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y. Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration. International journal of clinical and experimental pathology. 8(12):15836-44. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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