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Name :
GP repeat antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GP repeat Rabbit Polyclonal antibody. Positive WB detected in Recombinant protein. Positive IHC detected in human cerebellum tissue.

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
C9RAN antibody; GP repeat antibody; GPGPGPGP antibody; poly GP antibody; poly PG antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Peptide. Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: N/A

Background :
The C9orf72 “GGGGCC” repeat sequence codes five repeat peptide “GA repeat; GAGAGAGAGA”, “GP repeat; GPGPGPGPG”, “GR repeat; GRGRGRGRG”, “AP repeat; APAPAPAPA” and “PR repeat; PRPRPRPRP”. This antibody is used to detect the GP repeated sequence. The recombinant protein 6*His tag-SMARCA4 which contains the sequence “GPGPGPGPG” was used to detect this antibody.

References :
Cooper-Knock J, Higginbottom A, Stopford MJ. Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy. Acta neuropathologica. 130(1):63-75. 2015. Mackenzie IR, Frick P, Grässer FA. Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers. Acta neuropathologica. 130(6):845-61. 2015. Davidson Y, Robinson AC, Liu X. Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins. Neuropathology and applied neurobiology. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel