Name :
GPI antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GPI Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells, HeLa cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 63 kDa
Tested applications :
ELISA, WB, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
AMF antibody; AutOCrine motility factor antibody; g6pi antibody; Glucose 6 phosphate isomerase antibody; glucose phosphate isomerase antibody; GNPI antibody; GPI antibody; Neuroleukin antibody; NLK antibody; PGI antibody; PHI antibody; Phosphoglucose isomerase antibody; Phosphohexose isomerase antibody; SA 36 antibody; Sperm antigen 36 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GPI recombinant protein (Accession Number: NM_000175). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000
Background :
GPI(Glucose-6-phosphate isomerase),which is also named as autocrine motility factor (AMF), phosphoglucose isomerase(PGI), Neuroleukinis(NLK), phosphohexose isomerase(PHI), sperm antigen 36(SA-36), is a housekeeping cytosolic enzyme that plays a key role in both glycolysis and gluconeogenesis pathways. It is also a multifunctional protein that displays cytokine properties, eliciting mitogenic, motogenic, and differentiation activities, and has been implicated in tumor progression and metastasis(PMID:12783864). This protein can exsit as a homodimer in the catalytically active form and a monomer in the secreted form(PMID:11371164). It has 2 isoforms produced by alternative splicing.
References :
Lu Y, Cai G, Cui S. FHL2-driven molecular network mediated Septin2 knockdown inducing apoptosis in mesangial cell. Proteomics. 14(21-22):2485-97. 2014. Sun L, Song L, Wan Q. cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell research. 25(4):429-44. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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