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Name :
GPI antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GPI Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells, HeLa cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 63 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
AMF antibody; AutOCrine motility factor antibody; g6pi antibody; Glucose 6 phosphate isomerase antibody; glucose phosphate isomerase antibody; GNPI antibody; GPI antibody; Neuroleukin antibody; NLK antibody; PGI antibody; PHI antibody; Phosphoglucose isomerase antibody; Phosphohexose isomerase antibody; SA 36 antibody; Sperm antigen 36 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GPI recombinant protein (Accession Number: NM_000175). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000

Background :
GPI(Glucose-6-phosphate isomerase),which is also named as autocrine motility factor (AMF), phosphoglucose isomerase(PGI), Neuroleukinis(NLK), phosphohexose isomerase(PHI), sperm antigen 36(SA-36), is a housekeeping cytosolic enzyme that plays a key role in both glycolysis and gluconeogenesis pathways. It is also a multifunctional protein that displays cytokine properties, eliciting mitogenic, motogenic, and differentiation activities, and has been implicated in tumor progression and metastasis(PMID:12783864). This protein can exsit as a homodimer in the catalytically active form and a monomer in the secreted form(PMID:11371164). It has 2 isoforms produced by alternative splicing.

References :
Lu Y, Cai G, Cui S. FHL2-driven molecular network mediated Septin2 knockdown inducing apoptosis in mesangial cell. Proteomics. 14(21-22):2485-97. 2014. Sun L, Song L, Wan Q. cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell research. 25(4):429-44. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel