Name :
Anti-Bag1 Rabbit antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Bag1 Rabbit monoclonal antibody
Tested applications :
WB, IHC-P, ICC/IF, IP
Species reactivity :
Human, Mouse, Rat
Alternative names :
HAP; BAG-1; RAP46 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: A synthetic peptide of human Bag1
Clonality :
Monoclonal
Formulation :
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage instructions :
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Applications :
WB: 1/1000IHC: 1/20ICC/IF: 1/50IP: 1/20
Background :
Swiss-Prot Acc.Q99933.Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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