Name :
Anti-Bag3 Rabbit antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Bag3 Rabbit polyclonal antibody
Tested applications :
WB, ICC/IF, FC
Species reactivity :
Human
Alternative names :
BIS; MFM6; BAG-3; CAIR-1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant protein of human Bag3
Clonality :
Polyclonal
Formulation :
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage instructions :
Store at -20°C. Stable for 12 months from date of receipt.
Applications :
WB: 1/1000ICC/IF: 1/20FC: 1/20
Background :
Swiss-Prot Acc.O95817.Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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