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Name :
GPSM2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GPSM2 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue. Positive WB detected in HeLa cells, human brain tissue. Observed molecular weight by Western-blot: 66-70 kDa

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
GPSM2 antibody; LGN antibody; Mosaic protein LGN antibody; Pins antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GPSM2 recombinant protein (Accession Number: BC027732). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
GPSM2 belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. It may play a role in neuroblast division and in the development of normal hearing. Mutations in GPSM2 are associated with autosomal recessive nonsyndromic deafness (DFNB82), which is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss.

References :
Fukukawa C, Ueda K, Nishidate T, Katagiri T, Nakamura Y. Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells. Genes, chromosomes & cancer. 49(10):861-72. 2010. Seldin L, Poulson ND, Foote HP, Lechler T. NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. Molecular biology of the cell. 24(23):3651-62. 2013. Bhonker Y, Abu-Rayyan A, Ushakov K. The GPSM2/LGN GoLoco motifs are essential for hearing. Mammalian genome : official journal of the International Mammalian Genome Society. 27(1-2):29-46. 2016. Guo X, Gao S. Pins homolog LGN regulates meiotic spindle organization in mouse oocytes. Cell research. 19(7):838-48. 2009. Walsh T, Shahin H, Elkan-Miller T. Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. American journal of human genetics. 87(1):90-4. 2010.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel