Name :
GPSM2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GPSM2 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue. Positive WB detected in HeLa cells, human brain tissue. Observed molecular weight by Western-blot: 66-70 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
GPSM2 antibody; LGN antibody; Mosaic protein LGN antibody; Pins antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GPSM2 recombinant protein (Accession Number: BC027732). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
GPSM2 belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. It may play a role in neuroblast division and in the development of normal hearing. Mutations in GPSM2 are associated with autosomal recessive nonsyndromic deafness (DFNB82), which is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss.
References :
Fukukawa C, Ueda K, Nishidate T, Katagiri T, Nakamura Y. Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells. Genes, chromosomes & cancer. 49(10):861-72. 2010. Seldin L, Poulson ND, Foote HP, Lechler T. NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. Molecular biology of the cell. 24(23):3651-62. 2013. Bhonker Y, Abu-Rayyan A, Ushakov K. The GPSM2/LGN GoLoco motifs are essential for hearing. Mammalian genome : official journal of the International Mammalian Genome Society. 27(1-2):29-46. 2016. Guo X, Gao S. Pins homolog LGN regulates meiotic spindle organization in mouse oocytes. Cell research. 19(7):838-48. 2009. Walsh T, Shahin H, Elkan-Miller T. Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. American journal of human genetics. 87(1):90-4. 2010.
Related websites: https://www.medchemexpress.com/antibodies.html
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