Share this post on:

Name :
GR repeat antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GR repeat Rabbit Polyclonal antibody. Positive WB detected in Recombinant protein.

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
C9RAN antibody; GR repeat antibody; GRGRGRGRG antibody; GRGRGRGRGR antibody; Poly-GR antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Peptide. Purification method: Antigen Affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000

Background :
The C9orf72 “GGGGCC” repeat sequence codes five repeat peptide “GA repeat; GAGAGAGAGA”, “GP repeat; GPGPGPGPG”, “GR repeat; GRGRGRGRG”, “AP repeat; APAPAPAPA” and “PR repeat; PRPRPRPRP”. This antibody is used to detect the GR repeated sequence. The recombinant proteins GST-SNRPD1 and 6*His tag- SNRPD1 which contains the sequence “GRGRGRGRGRGRGRGRGR” were used to detect this antibody. Both proteins can be recognized by the antibody 23978-1-AP.

References :
Mizielinska S, Grönke S, Niccoli T. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science (New York, N.Y.). 345(6201):1192-4. 2014. Cooper-Knock J, Higginbottom A, Stopford MJ. Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy. Acta neuropathologica. 130(1):63-75. 2015. Zhang K, Donnelly CJ, Haeusler AR. The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature. 525(7567):56-61. 2015. Mackenzie IR, Frick P, Grässer FA. Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers. Acta neuropathologica. 130(6):845-61. 2015. Davidson Y, Robinson AC, Liu X. Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins. Neuropathology and applied neurobiology. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites:
Popular product recommendations:
Hes1 Antibody
JAK2 Antibody (YA330)

Share this post on:

Author: Gardos- Channel