Name :
GRAMD4 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GRAMD4 Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells. Observed molecular weight by Western-blot: 66, 140 kDa
Tested applications :
ELISA, WB
Species reactivity :
Human; other species not tested.
Alternative names :
dA59H18.1 antibody; Death inducing protein antibody; DIP antibody; dJ439F8.1 antibody; GRAM domain containing 4 antibody; GRAMD4 antibody; KIAA0767 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GRAMD4 recombinant protein (Accession Number: XM_047441209). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000
Background :
GRAMD4 also termed as Death inducing protein is a 578 amino-acid protein, which contains 1 GRAM domain. GRAMD4 as a multi-pass membrane protein localizes in the Mitochondrion membrane. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows up-regulation in mitochondria by E2F-1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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