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Name :
Granzyme A antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Granzyme A Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive WB detected in Jurkat cells, mouse kidney tissue. Observed molecular weight by Western-blot: 60kd

Tested applications :

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
CTL tryptase antibody; CTLA3 antibody; Fragmentin 1 antibody; Granzyme 1 antibody; Granzyme A antibody; GZMA antibody; H factor antibody; Hanukkah factor antibody; HFSP antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Granzyme A recombinant protein (Accession Number: NM_006144). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
Granzyme A is necessary for target cell lysis in cell-mediated immune responses. It activates mitochondrial outer membrane permeabilization- and caspase-independent cell death pathways by cleaving the mitochondrial complex I component NDUFS3after lys56. This protein has 2 isoforms produced by alternative promoter usage.

References :
Chen CY, Xie QM, Xue Y. Characterization of cytotoxicity-related gene expression in response to virulent Marek’s disease virus infection in the bursa of Fabricius. Research in veterinary science. 94(3):496-503. 2013.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel