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Name :
GRIM19 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GRIM19 Rabbit Polyclonal antibody. Positive IP detected in HEK-293 cells. Positive WB detected in human placenta tissue, HEK-293 cells, HeLa cells, Jurkat cells, MCF7 cells. Positive IHC detected in human prostate cancer tissue, human heart tissue, human kidney tissue. Positive IF detected in MCF-7 cells, HeLa cells. Observed molecular weight by Western-blot: 16.5kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
B16.6 antibody; CDA016 antibody; CGI 39 antibody; CI B16.6 antibody; Complex I B16.6 antibody; GRIM 19 antibody; GRIM19 antibody; NDUFA13 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GRIM19 recombinant protein (Accession Number: NM_015965). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:20-1:200

Background :
GRIM19(Gene associated with retinoic and interferon-induced mortality 19 protein) is also named as NDUFA13 ,CI-B16.6 and belongs to the complex I NDUFA13 subunit family.t GRIM-19 may distribute in the mitochondria and/or nucleus depending on the cell type.Alternatively, its cellular localization may be regulated by post-translational modifications such as phosphorylation and acetylation. Lastly, GRIM-19 may exist in different isoforms that may be distributed in distinct cellular locations(PMID:12628925).

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel