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Name :
GRP94 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GRP94 Mouse Monoclonal antibody. Positive WB detected in Human heart, human liver tissue, human lung tissue, NIH/3T3 cells. Positive IF detected in Hela cells, HepG2 cells, MCF-7 cells. Positive FC detected in HeLa cells. Observed molecular weight by Western-blot: 95kd

Tested applications :

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
ECGP antibody; GP96 antibody; GRP 94 antibody; GRP94 antibody; HSP90B1 antibody; TRA1 antibody; Tumor rejection antigen 1 antibody

Immunogen :

Isotype :
Mouse IgM

Preparation :
This antibody was obtained by immunization of GRP94 recombinant protein (Accession Number: BC009195). Purification method: Caprylic acid/ammonium sulfate precipitation.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IF: 1:10-1:100

Background :
HSP90 proteins are highly conserved molecular chaperones, which normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 (GP96 or GRP94) is an endoplasmic reticulum paralogue of the cytosolic HSP90. As a major ER chaperone to mediate the UPR and a master chaperone for Toll-like receptors (TLRs), HSP90b1 chaperones peptides to MHC class I molecules of dendritic cells and other antigen-presenting cells, as well as facilitating the assembly of immunoglobulin. The protein is also involved in many other bio-processes. This antibody was generated against the N-terminal region of full-length HSP90b1.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel