Share this post on:

Name :
GSTT1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GSTT1 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, HepG2 cells, mouse brain tissue, mouse liver tissue, rat liver tissue. Positive IHC detected in human liver tissue, human brain tissue, human heart tissue, human kidney tissue, human lung tissue, human ovary tissue, human skin tissue, human spleen tissue, human testis tissue. Observed molecular weight by Western-blot: 28 kDa, 30 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
Glutathione transferase T1 1 antibody; GST class theta 1 antibody; GSTT1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GSTT1 recombinant protein (Accession Number: NM_000853). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200

Background :
GSTT1 belongs to the GST superfamily and Theta family. It is a conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GSTT1 acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. It displays glutathione peroxidase activity with cumene hydroperoxide. GSTM1 and GSTT1 has been suggested as a risk factor in various cancers. GSTT1 is important in the detoxification of unidentified xenobiotics in the large intestine.

References :
Arakawa S, Fujimoto K, Kato A. Evaluation of hepatic glutathione transferase Mu 1 and Theta 1 activities in humans and mice using genotype information. Drug metabolism and disposition: the biological fate of chemicals. 40(3):497-503. 2012. Sato Y, Kubo S, Takemura S. Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan. International journal of clinical and experimental pathology. 7(8):4745-54. 2014. Gi M, Fujioka M, Yamano S. Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice. Toxicological sciences : an official journal of the Society of Toxicology. 145(1):196-208. 2015. Gi M, Fujioka M, Yamano S. Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters. The Journal of toxicological sciences. 40(5):647-56. 2015. Zhang L, Zong C, Ichihara S. A trial to find appropriate animal models of dichloropropane-induced cholangiocarcinoma based on the hepatic distribution of glutathione S-transferases. Journal of occupational health. 57(6):548-54. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites:
Popular product recommendations:
SN38 Antibody (YA923)
p38 Antibody
Histone H4 (acetyl K5) Antibody: Histone H4 (acetyl K5) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 11 kDa, targeting to Histone H4(acetyl K5). It can be used for WB,ICC/IF,IHC-P,IP,ChIP,CUT&Tag-seq assays with tag free, in the background of Human, Mouse, Rat.

Share this post on:

Author: Gardos- Channel