Name :
Anti-Bcl-2 (3H5) Mouse antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Bcl-2 (3H5) Mouse monoclonal antibody
Tested applications :
ICC/IF, WB, IHC-P
Species reactivity :
Human, Mouse, Rat, Chicken
Alternative names :
Immunogen :
Isotype :
IgG1
Preparation :
Antigen: Synthetic Peptide of Bcl-2
Clonality :
Monoclonal
Formulation :
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Storage instructions :
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Applications :
IF: 1/50-200WB: 1/1000-2000IHC: 1/200
Background :
Swiss-Prot Acc.P10415.Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
References :
Aqueous extract of Fritillariae cirrhosae induces cellular apoptosis through activation of STATs-mediated immunomodulation
Related websites: https://www.medchemexpress.com/antibodies.html
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