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Name :
GUSB antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
GUSB Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue, HL-60 cells, mouse heart tissue. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 78kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
Beta G1 antibody; Beta glucuronidase antibody; FLJ39445 antibody; glucuronidase antibody; beta antibody; GUSB antibody; MPS7 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of GUSB recombinant protein (Accession Number: NM_000181). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
The GUSB gene encodes beta-glucuronidase, a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans.It is a tetrameric glycoprotein composed of identical subunits.GUSB plays an important role in the degradation of dermatan and keratan sulfates.It has two isoforms.

References :
Wang AL, Lukas TJ, Yuan M, Du N, Handa JT, Neufeld AH. Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration. PloS one. 4(4):e5304. 2009. Ishisaka A, Kawabata K, Miki S. Mitochondrial dysfunction leads to deconjugation of quercetin glucuronides in inflammatory macrophages. PloS one. 8(11):e80843. 2013.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel