Name :
GZMB antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GZMB Rabbit Polyclonal antibody. Positive WB detected in HL-60 cells. Positive IHC detected in human lymphoma tissue. Positive IF detected in Hela cells. Observed molecular weight by Western-blot: 33kd
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human; other species not tested.
Alternative names :
CCPI antibody; CGL 1 antibody; CGL1 antibody; CSP B antibody; CSPB antibody; CTLA1 antibody; CTSGL1 antibody; Endogenous granzyme B antibody; Granzyme B antibody; GZMB antibody; HLP antibody; SECT antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GZMB recombinant protein (Accession Number: NM_004131). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:20-1:200
Background :
GZMB(Granzyme B) is also named as CGL1, CSPB, CTLA1, GRB and belongs to the Granzyme subfamily. This enzyme is necessary for target cell lysis in cell-mediated immune responses. The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can also cleave the BH3-only protein, BID, to promote caspase-independent mitochondrial permeabilization(PMID:17283187).GzmB induces laminB degradation in isolated nuclei less efficiently than GzmA(PMID:11331782).This full length protein has 2 glycosylation sites and a signal peptide.Unglycosylated human granzyme B is 26 kDa and g high mannose glycosylated is 32 kDa and only 32kDa or smaller forms of granzyme B are accumulated within nuclei(PMID:8626751).
References :
Li P, Zheng G, Yang Y. Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis. Cellular and molecular life sciences : CMLS. 67(18):3197-208. 2010. Cho YT, Lin JW, Chen YC. Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features. Journal of the American Academy of Dermatology. 70(3):539-48. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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