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Name :
HAX1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HAX1 Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive IP detected in mouse brain tissue. Positive WB detected in HeLa cells, human brain tissue. Observed molecular weight by Western-blot: 32 kDa

Tested applications :

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
FLJ17042 antibody; FLJ18492 antibody; FLJ93803 antibody; HAX 1 antibody; HAX1 antibody; HCLS1 assOCiated protein X 1 antibody; HCLSBP1 antibody; HS1 assOCiating protein X 1 antibody; HS1 binding protein 1 antibody; HS1BP1 antibody; HSP1BP 1 antibody; SCN3 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HAX1 recombinant protein (Accession Number: NM_006118). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:1000IP: 1:200-1:1000IHC: 1:20-1:200

Background :
HAX1, also named as HS1BP1, is a 32 kDa protein that is ubiquitously expressed. Hax1 has been demonstrated to be a negative regulator of apoptosis in many immune cell types. Furthermore, Hax1 has been shown to have additional roles in regulating cell motility and adhesion, and is overexpressed in many types of cancer. Kristina and Cavnar demonstrate in their paper validation of two research antibodies including Proteintech’s anti-Hax1 (11266-1-AP). They have evidence that the rabbit anti-Hax1 (11266-1-AP, Proteintech Group Inc.) results in a more robust and consistent detection of Hax1.

References :
Cavnar PJ, Berthier E, Beebe DJ, Huttenlocher A. Hax1 regulates neutrophil adhesion and motility through RhoA. The Journal of cell biology. 193(3):465-73. 2011.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel