Name :
Anti-Bcr Rabbit antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Bcr Rabbit monoclonal antibody
Tested applications :
WB, IHC-P, ICC/IF, FC, IP
Species reactivity :
Human
Alternative names :
Immunogen :
Isotype :
IgG
Preparation :
Antigen: A synthetic peptide of human Bcr
Clonality :
Monoclonal
Formulation :
50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
Storage instructions :
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Applications :
WB: 1/2000IHC: 1/20ICC/IF: 1/50FC: 1/20IP: 1/20
Background :
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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