Name :
Anti-BCRP/ABCG2 (2F7) Mouse antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
BCRP/ABCG2 (2F7) Mouse monoclonal antibody
Tested applications :
WB, IHC-P, ICC/IF, FC
Species reactivity :
Human, Mouse, Monkey
Alternative names :
Immunogen :
Isotype :
Mouse IgG1
Preparation :
Antigen: Purified recombinant fragment of human ABCG2 expressed in E. Coli.
Clonality :
Monoclonal
Formulation :
Ascitic fluid containing 0.03% sodium azide.
Storage instructions :
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Applications :
WB: 1/500 – 1/2000IHC: 1/200 – 1/1000ICC: 1/200 – 1/1000FC: 1/200 – 1/400ELISA: 1/10000
Background :
Swiss-Prot Acc.Q9UNQ0.The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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