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Name :
Anti-BCRP/ABCG2 (2F7) Mouse antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
BCRP/ABCG2 (2F7) Mouse monoclonal antibody

Tested applications :

Species reactivity :
Human, Mouse, Monkey

Alternative names :

Immunogen :

Isotype :
Mouse IgG1

Preparation :
Antigen: Purified recombinant fragment of human ABCG2 expressed in E. Coli.

Clonality :

Formulation :
Ascitic fluid containing 0.03% sodium azide.

Storage instructions :
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Applications :
WB: 1/500 – 1/2000IHC: 1/200 – 1/1000ICC: 1/200 – 1/1000FC: 1/200 – 1/400ELISA: 1/10000

Background :
Swiss-Prot Acc.Q9UNQ0.The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel