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Name :
hD53; TPD52L1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
hD53; TPD52L1 Rabbit Polyclonal antibody. Positive IHC detected in human prostate tissue. Positive IF detected in MCF-7 cells. Positive WB detected in MCF7 cells. Positive IP detected in MCF-7 cells. Observed molecular weight by Western-blot: 25 kDa

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
D53 antibody; hD53 antibody; TDP53 antibody; TPD52L1 antibody; TPD52L2 antibody; TPD53 antibody; tumor protein D52 like 1 antibody; Tumor protein D53 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of hD53; TPD52L1 recombinant protein (Accession Number: NM_001003396). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:1000IHC: 1:20-1:200IF: 1:20-1:200

Background :
Tumor protein D52-like 1 (TPD52L1) gene, also known as hD53, encodes a member of the tumor protein D52 (TPD52) family. TPD52-like proteins are coiled-coil motif-bearing proteins first identified through their expression in human breast carcinoma, which have been proposed to represent signaling intermediates and regulators of vesicle trafficking. hD53 may form homo- or heterodimers with other TPD52 family members, and it is reported to be involved in cell proliferation and calcium signaling. Four variants resulted from alternative splicing have been predicated and this antibody is expected to recognize all the variants.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel