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Name :
HDGF antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HDGF Mouse Monoclonal antibody. Positive IF detected in Hela cells. Positive IHC detected in human kidney tissue, human brain tissue, human colon cancer tissue, human epididymis tissue, human heart tissue, human liver cancer tissue, human liver tissue, human lung tissue, human ovary tissue, human ovary tumor tissue, human placenta tissue, human renal cell carcinoma tissue, human skin tissue, human spleen tissue. Positive WB detected in HeLa cells, human testis tissue. Observed molecular weight by Western-blot: 40 kDa

Tested applications :

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
DKFZp686J1764 antibody; FLJ96580 antibody; HDGF antibody; Hepatoma derived growth factor antibody; HMG 1L2 antibody; HMG1L2 antibody

Immunogen :

Isotype :
Mouse IgG1

Preparation :
This antibody was obtained by immunization of HDGF recombinant protein (Accession Number: NM_004494). Purification method: Protein G purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100

Background :
HDGF, also named as HMG1L2, belongs to the HDGF family. It is a heparin-binding protein, with mitogenic activity for fibroblasts. HDGF acts as a transcriptional repressor. It plays important roles in the development and progression of cancers. HDGF may have a synergistic effect with VEGF during cancer development and Progression. (PMID:20848225)

References :
Li SZ, Zhao YB, Cao WD. The expression of hepatoma-derived growth factor in primary central nervous system lymphoma and its correlation with angiogenesis, proliferation and clinical outcome. Medical oncology (Northwood, London, England). 30(3):622. 2013. Bao CH, Wang XT, Ma W. Irradiated fibroblasts promote epithelial-mesenchymal transition and HDGF expression of esophageal squamous cell carcinoma. Biochemical and biophysical research communications. 458(2):441-7. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel