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Name :
HECTD1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HECTD1 Rabbit Polyclonal antibody. Positive IF detected in Hela cells. Positive IHC detected in human kidney tissue, human brain tissue. Positive IP detected in mouse brain tissue. Positive WB detected in human brain tissue. Observed molecular weight by Western-blot: 290kd

Tested applications :

Species reactivity :
Human, Mouse; other species not tested.

Alternative names :
E3 ligase for inhibin receptor antibody; EULIR antibody; FLJ38315 antibody; HECT domain containing 1 antibody; HECTD1 antibody; KIAA1131 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HECTD1 recombinant protein (Accession Number: BC006237). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100

Background :
HECTD1 (E3 ubiquitin-protein ligase), which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates,may be required for development of the head mesenchyme and neural tube closure.It is also involved in sporadic Parkinson’s disease(PMID:16714300).This protein is specific to HECTD1.

References :
Li W, Hu Y, Oh S. Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation. Molecular cell. 59(2):188-202. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel