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Name :
HELLS antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HELLS Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue. Positive IF detected in HepG2 cells. Positive IP detected in mouse testis tissue. Positive WB detected in K-562 cells, DU 145 cells, mouse testis tissue, mouse thymus tissue, PC-3 cells. Observed molecular weight by Western-blot: 97kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
FLJ10339 antibody; helicase antibody; lymphoid antibody; HELLS antibody; LSH antibody; Lymphoid specific helicase antibody; Nbla10143 antibody; PASG antibody; SMARCA6 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HELLS recombinant protein (Accession Number: BC031004). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:1000-1:10000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100

Background :
Lymphoid-specific helicase(HELLS) ia a member of the SNF2 family of chromatin remodeling proteins that is required for development and survival. It’s required for de novo or maintenance DNA methylation, which mediated the silencing of the imprinted CDKN1C gene. Also it involved in formation and organization of heterochromatin that regulate transcription and mitosis.

References :
Dunican DS, Cruickshanks HA, Suzuki M. Lsh regulates LTR retrotransposon repression independently of Dnmt3b function. Genome biology. 14(12):R146. 2013.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel