Name :
HER2/ErbB2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HER2/ErbB2 Mouse Monoclonal antibody. Positive IHC detected in human breast cancer tissue. Positive FC detected in HeLa cells.
Tested applications :
ELISA, IHC, FC
Species reactivity :
Human; other species not tested.
Alternative names :
CD340 antibody; ERBB2 antibody; HER 2 antibody; HER 2/neu antibody; HER2 antibody; MLN 19 antibody; MLN19 antibody; NEU antibody; NGL antibody; p185 antibody; p185erbB2 antibody; Proto oncogene c ErbB 2 antibody; Proto oncogene Neu antibody; TKR1 antibody
Immunogen :
Isotype :
Mouse IgG2b
Preparation :
This antibody was obtained by immunization of HER2/ErbB2 recombinant protein (Accession Number: NM_004448). Purification method: Protein A purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: IHC: 1:50-1:400
Background :
HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase- mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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