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Name :
HERP antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HERP Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, HeLa cells, SW 1990 cells. Positive IHC detected in human lung cancer tissue, human heart tissue, human kidney tissue, human liver tissue, human ovary tissue, human skin tissue, human testis tissue. Observed molecular weight by Western-blot: 52 kDa

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
HERP antibody; HERPUD1 antibody; KIAA0025 antibody; Mif1 antibody; SUP antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HERP recombinant protein (Accession Number: NM_014685). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1), also called HERP or MIF1, is component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. HERP is strongly induced by ER stress but rapidly degraded by proteasome. HERP interacts with members of the ubiquilin family, which function as a shuttle factor to deliver ubiquitinated substrates to the proteasome for degradation. HERP is present in activated microglia in senile plaques in the brain of patients with Alzheimer disease, and there is evidence suggesting HERP increase nigro-striatal dopaminergic activity and is able to improve symptoms in patients with Parkinson’s disease, levodopa-related dyskinesias and Tardive dyskinesia.

References :
Hao L, Vassena R, Wu G. The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome. Biology of reproduction. 80(5):944-53. 2009. Meir O, Dvash E, Werman A, Rubinstein M. C/EBP-beta regulates endoplasmic reticulum stress-triggered cell death in mouse and human models. PloS one. 5(3):e9516. 2010. Zhuo JM, Kruger WD, Praticò D. The Herp protein pathway is not involved in the pro-amyloidogenic effect of hyperhomocysteinemia. Journal of Alzheimer’s disease : JAD. 20(2):569-76. 2010. Tuusa JT, Petäjä-Repo UE. Phe27Cys polymorphism of the human delta opioid receptor predisposes cells to compromised calcium signaling. Molecular and cellular biochemistry. 351(1-2):173-81. 2011.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel