Name :
HES1 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to HES1
Tested applications :
WB
Species reactivity :
Rat
Alternative names :
HES1 antibody; HES-1 antibody; HHL antibody; HRY antibody; bHLHb39 antibody; transcription factor HES-1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 151-280 of human HES1 (NP_005515.1).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5′-CACNAG-3′ with high affinity and on E-box motifs: 5′-CANNTG-3′ with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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