Name :
HEXB antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HEXB Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue. Positive WB detected in Jurkat cells, HEK-293 cells, HeLa cells, mouse kidney tissue, mouse lung tissue. Observed molecular weight by Western-blot: 63kd
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
ENC 1AS antibody; HCC 7 antibody; HEXB antibody; Hexosaminidase subunit B antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HEXB recombinant protein (Accession Number: NM_000521). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
The HEXB(Beta-hexosaminidase subunit beta) gene encodes the beta subunit of the enzyme hexosaminidase, which is involved in the breakdown of gangliosides. It is responsible for the degradation of GM2 gangliosides, and has a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.It has a calculated molecular mass of about 63 KDa.
References :
Bastow ER, Last K, Golub S, Stow JL, Stanley AC, Fosang AJ. Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo. Biology open. 1(4):318-28. 2012. Sims-Robinson C, Bakeman A, Rosko A, Glasser R, Feldman EL. The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain. Molecular neurobiology. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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