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Name :
HEXB antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HEXB Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue. Positive WB detected in Jurkat cells, HEK-293 cells, HeLa cells, mouse kidney tissue, mouse lung tissue. Observed molecular weight by Western-blot: 63kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
ENC 1AS antibody; HCC 7 antibody; HEXB antibody; Hexosaminidase subunit B antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HEXB recombinant protein (Accession Number: NM_000521). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
The HEXB(Beta-hexosaminidase subunit beta) gene encodes the beta subunit of the enzyme hexosaminidase, which is involved in the breakdown of gangliosides. It is responsible for the degradation of GM2 gangliosides, and has a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.It has a calculated molecular mass of about 63 KDa.

References :
Bastow ER, Last K, Golub S, Stow JL, Stanley AC, Fosang AJ. Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo. Biology open. 1(4):318-28. 2012. Sims-Robinson C, Bakeman A, Rosko A, Glasser R, Feldman EL. The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain. Molecular neurobiology. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel