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Name :
HGD antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HGD Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue. Positive WB detected in human liver tissue, HeLa cells. Observed molecular weight by Western-blot: 50kd

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
AKU antibody; FLJ94126 antibody; HGD antibody; HGO antibody; Homogentisate 1 antibody; 2 dioxygenase antibody; Homogentisate oxygenase antibody; Homogentisic acid oxidase antibody; Homogentisicase antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HGD recombinant protein (Accession Number: BC020792). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200

Background :
Homogentisate1,2-dioxygenase (HGD), also named as HGO, is a mononuclear Fe(II)-dependent oxygenase that catalyzes the third step in the pathway for the catabolism of tyrosine, the conversion of homogentisate (HG) to maleylacetoacetate (MAA) and it can exsit as a dimer or trimer(PMID:14678794). HGD consists of a single type of subunit with no intermolecular disulfide bridges and requires Fe2+ as a cofactor(PMID: 7705358). Defects in HGD are the cause of alkaptonuria (AKU)(PMID:10594001).

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel