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Name :
Anti-beta 2 Microglobulin Rabbit antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
beta 2 Microglobulin Rabbit polyclonal antibody

Tested applications :
WB, IHC-P, FC, IP

Species reactivity :
Human, Mouse, Rat

Alternative names :
IMD43 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
Antigen: Recombinant protein of human beta 2 Microglobulin

Clonality :
Polyclonal

Formulation :
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage instructions :
Store at -20°C. Stable for 12 months from date of receipt.

Applications :
WB: 1/1000IHC: 1/200FC: 1/20IP: 1/20

Background :
Swiss-Prot Acc.P61769.Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel