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Name :
Anti-beta Arrestin 1 (6A1) Mouse antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
beta Arrestin 1 (6A1) Mouse monoclonal antibody

Tested applications :

Species reactivity :

Alternative names :
ARB1; ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1. antibody

Immunogen :

Isotype :

Preparation :
Antigen: Recombinant human β-Arrestin 1 protein.

Clonality :

Formulation :
Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.

Storage instructions :
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Applications :
WB: 1/500

Background :
Swiss-Prot Acc.P49407.Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling. Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel