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Name :
Anti-beta Catenin (5D6) Mouse antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
beta Catenin (5D6) Mouse monoclonal antibody

Tested applications :

Species reactivity :
Human, Mouse, Rat

Alternative names :
Beta catenin ;Beta-catenin ;Cadherin associated protein ;Catenin (cadherin associated protein) antibody; beta 1 antibody; 88kDa ;Catenin beta 1 ;Catenin beta-1 ;CATNB ;CHBCAT ;CTNB1_HUMAN ;CTNNB ;CTNNB1 ;DKFZp686D02253 ;FLJ25606 ;FLJ37923 ;OTTHUMP00000162082 ;OTTHUMP00000165222 ;OTTHUMP00000165223 ;OTTHUMP00000209288 ;OTTHUMP00000209289. antibody

Immunogen :

Isotype :

Preparation :
Antigen: Purified recombinant human β-Catenin protein fragments expressed in E.coli.

Clonality :

Formulation :
PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.

Storage instructions :
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

Applications :
WB: 1/1000

Background :
Swiss-Prot Acc.P35222.Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel