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Name :
HLA-E antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HLA-E Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, human kidney tissue. Observed molecular weight by Western-blot: 40kd

Tested applications :

Species reactivity :
Human; other species not tested.

Alternative names :
DKFZp686P19218 antibody; EA1.2 antibody; EA2.1 antibody; HLA 6.2 antibody; HLA E antibody; HLAE antibody; HLA-E antibody; MHC antibody; MHC class I antigen E antibody; QA1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HLA-E recombinant protein (Accession Number: NM_005516). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000

Background :
Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I and class II. This class I molecules are membrane glycoproteins composed of a heavy (alpha) chain which is encoded by a HLA class I gene, and β2-microglobulin light (beta) chain. The most extensively characterized members of the HLA class I gene family are the genes encoding the major transplantation antigenes, HLA-A, B and C. HLA-E is a non-classical MHC class I molecule. (PMID: 667938; 3375250; 2249951)

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel