Name :
HMG20B antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HMG20B Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells. Positive IF detected in HeLa cells. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 35-36 kDa
Tested applications :
ELISA, WB, IHC, IP, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
BRAF25 antibody; BRAF35 antibody; BRCA2 assOCiated factor 35 antibody; FLJ26127 antibody; high mobility group 20B antibody; HMG box containing protein 20B antibody; HMG20B antibody; HMGX2 antibody; HMGXB2 antibody; PP7706 antibody; pp8857 antibody; SMARCE1 related protein antibody; SMARCE1r antibody; SOXL antibody
Immunogen :
Human HMG20B Recombinant protein (His tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HMG20B recombinant protein (Accession Number: NM_006339). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:50-1:500
Background :
CoREST (corepressor of repressor element-1-silencing transcription factor) is a chromatin- modifying complex that was first identified as a regulator of neuronal gene expression, having a eseential role in neuronal differentiation [PMID:10449787]. The CoREST complex is recruited by REST (RE1-silencing transcription factor) that recognizes the 21-nucleotide RE-1 sequence in the promoter of more than 1,700 different target genes in human and mouse [PMID:15240883]. HMGB20B is one component of the CoREST complex, which mediates chromatin remodeling and repression of specific genes involved in neuronal differentiation through modulation of chromatin structure [PMID:19997604].
References :
Esteghamat F, van Dijk TB, Braun H. The DNA binding factor Hmg20b is a repressor of erythroid differentiation. Haematologica. 96(9):1252-60. 2011.
Related websites: https://www.medchemexpress.com/antibodies.html
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