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Name :
HMG20B antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HMG20B Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells. Positive IF detected in HeLa cells. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 35-36 kDa

Tested applications :

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
BRAF25 antibody; BRAF35 antibody; BRCA2 assOCiated factor 35 antibody; FLJ26127 antibody; high mobility group 20B antibody; HMG box containing protein 20B antibody; HMG20B antibody; HMGX2 antibody; HMGXB2 antibody; PP7706 antibody; pp8857 antibody; SMARCE1 related protein antibody; SMARCE1r antibody; SOXL antibody

Immunogen :
Human HMG20B Recombinant protein (His tag)

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HMG20B recombinant protein (Accession Number: NM_006339). Purification method: Antigen affinity purified.

Clonality :

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:50-1:500

Background :
CoREST (corepressor of repressor element-1-silencing transcription factor) is a chromatin- modifying complex that was first identified as a regulator of neuronal gene expression, having a eseential role in neuronal differentiation [PMID:10449787]. The CoREST complex is recruited by REST (RE1-silencing transcription factor) that recognizes the 21-nucleotide RE-1 sequence in the promoter of more than 1,700 different target genes in human and mouse [PMID:15240883]. HMGB20B is one component of the CoREST complex, which mediates chromatin remodeling and repression of specific genes involved in neuronal differentiation through modulation of chromatin structure [PMID:19997604].

References :
Esteghamat F, van Dijk TB, Braun H. The DNA binding factor Hmg20b is a repressor of erythroid differentiation. Haematologica. 96(9):1252-60. 2011.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
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Author: Gardos- Channel